Abstract
Plants of the genus Callicarpa are known to possess several medicinal effects. The constituents of the Taiwan endemic plant Callicarpa hypoleucophylla have never been studied. Therefore, C. hypoleucophylla was selected for our phytochemical investigation. Two new clerodane-type diterpenoids, named callihypolins A (1) and B (2), along with seven known compounds were isolated from the leaves and twigs of the Lamiaceae plant C. hypoleucophylla and then characterized. The structures of compounds 1 and 2 were elucidated by spectroscopic data analysis, specifically, two-dimension nuclear magnetic resonance (NMR). The anti-inflammatory activity of compounds 1–9 based on the suppression of superoxide anion generation and elastase release was evaluated. Among the isolates, compounds 2–4 showed anti-inflammatory activity (9.52−32.48% inhibition at the concentration 10 μm) by suppressing superoxide anion generation and elastase release. Our findings not only expand the description of the structural diversity of the compounds present in plants of the genus Callicarpa but also highlight the possibility of developing anti-inflammatory agents from Callicarpa endemic species.
Highlights
Introduction190ofspecies of herbaceous is a genus aboutof190 species herbaceous plants. Theplants
Callicarpa is a of genus about190ofspecies of herbaceous is a genus aboutof190 species herbaceous plants
The leaves and twigs of C. hypoleucophylla were extracted with 95% ethanol; the yielded extracts extracts were suspended in H2 O and extracted with ethyl acetate (EtOAc)
Summary
190ofspecies of herbaceous is a genus aboutof190 species herbaceous plants. Theplants. The phytochemical investigation of this genus has resulted in the phytochemical investigation of this genus has resulted in the identification of diterpenoids, identification of diterpenoids, phenylethanoids, phenypropanoids, and flavonoids. These components display various biological display various biological effects, such as anti-inflammatory [4,5,6], anti-platelet aggregation effects, such as anti-inflammatory [4,5,6], anti-platelet aggregation [7], hemostatic [8], antioxidative [9– [7], hemostatic [9,10], cytotoxic [6,11,12], and neuroprotective [13], antitubercular.
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