Abstract
From the leaves of Salvia involucrata Cav., eight clerodane diterpenoids were isolated, of which 1−3 have not been previously described. Their structures were established by spectroscopic and spectrometric means and named as involucratin A (1), involucratin B (2), and involucratin C (3). The absolute configuration of compounds 1 and 3 was established using a combination of experimental and theoretical ECD data, whereas the one for compound 2 was determined by NOESY experiments together with ECD and DP4+ statistical analysis. Furthermore, the known clerodane compounds (5R,7R,8S,9R,10R,12R)-7-hydroxycleroda-1,3,13(16),14-tetraene-17,12;18,19-diolide (4), (‒)-hardwickiic acid (5), 1-deoxybacrispine (6), 7α-hydroxybacchotricuneatin A (7), and kingidiol (8), along with the flavonoid salvigenin, and a mixture of ursolic and oleanolic acids were also isolated. The antiproliferative activity of compounds 1‒3, 5, and 7, 8 was evaluated against a panel of cancer cell-lines (six strains) using the sulforhodamine B assay.
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