Clearing the air: Uniquely engaging furin as an approach to cystic fibrosis therapy

Abstract

In this issue of Cell Chemical Biology, Douglas etal. describe a potent, specific, and cell-permeable furin inhibitor that interacts with a cryptic binding site to rescue hallmarks of cystic fibrosis in human exvivo models. BOS-318 holds promise for development of therapeutics targeting an array of furin-dependent pathologies.