Abstract
Immune complexes of 125I-HSA-rat anti-HSA formed in vivo under conditions of antibody excess were rapidly cleared from the circulation of both normal and leukaemic Hooded rats. In HSA-immune rats most of the 125I-HSA present in the blood was found to be cell-bound, but a proportion was present as circulating immune complexes that could be precipitated from plasma by 2.5% polyethylene glycol. There was no evidence that clearance of a soluble antigen was impaired in leukaemic animals.
Highlights
THE CLEARANCE of antigen from the tem in animals bearing tumours may be circulation of an animal with specific anti- responsible for the continued presence of body to that antigen
Most of the immune com- ance from circulation of complexes formed plexes formed in circulation that are in vivo between radiolabelled human of a size greater than 1 IS ( > Ag2Ab2) are serum albumin (HSA) and specific antirapidly cleared by the mononuclear phago- body
We have monitored the clearance of cyte system. in particular by the Kupffer the immune complexes from circulation, cells of the liver
Summary
Summary.-Immune complexes of 125I-HSA-rat anti-HSA formed in vivo under conditions of antibody excess were rapidly cleared from the circulation of both normal and leukaemic Hooded rats. THE CLEARANCE of antigen from the tem in animals bearing tumours may be circulation of an animal with specific anti- responsible for the continued presence of body to that antigen 1951) is dependent on a number of factors, To investigate the immune clearance perhaps the most important being the system in normal and tumour-bearing ratio of antigen to antibody in circulation animals we have followed the disappear-. Smaller immune gen and as the decrease in radioactivity complexes, formed in antigen excess, have that was precipitable from plasma by been found to remain longer in circulation, 2.5% polyethylene glycol. Immune complexes containing tumour antigen have been found in the sera of tumour-bearing animals (Thomson et al, 1973) and the presence
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