Clear Cell Renal Cell Carcinoma

Abstract

Renal cell carcinoma, clear cell type, forming a mass in the lower and mid portion of the kidney. Which is the most common subtype of renal cell carcinoma?a.Clear cellb.Papillaryc.Chromophobed.Unclassified Answer: a. Clear cell Clear cell renal cell carcinoma is the most common subtype of renal cell carcinoma (RCC), comprising 65% to 70% of RCC.1Moch H. Humphrey P.A. Ulbright T.M. Reuter V.E. WHO Classification of Tumours of the Urinary System and Male Genital Organs.4th ed. IARC Press, Lyon, France2016Google Scholar Papillary RCC comprises 15% to 20% and chromophobe RCC comprises 5% to 7% of RCC.1Moch H. Humphrey P.A. Ulbright T.M. Reuter V.E. WHO Classification of Tumours of the Urinary System and Male Genital Organs.4th ed. IARC Press, Lyon, France2016Google Scholar Other renal cell tumor subtypes include collecting duct carcinoma, renal medullary carcinoma, mucinous tubular and spindle cell carcinoma, RCC unclassified, papillary adenoma, and oncocytoma. Recently described renal cell tumors include multilocular cystic renal neoplasm of low malignant potential, MiT family translocation RCC, tubulocystic RCC, acquired cystic disease–associated RCC, clear cell papillary RCC, succinate dehydrogenase–deficient RCC, and hereditary leiomyomatosis and RCC-associated RCC. Additional emerging/provisional entities include oncocytic RCC occurring after neuroblastoma, thyroid-like follicular RCC, ALK rearrangement–associated RCC, and RCC with (angio)leiomyomatous stroma.1Moch H. Humphrey P.A. Ulbright T.M. Reuter V.E. WHO Classification of Tumours of the Urinary System and Male Genital Organs.4th ed. IARC Press, Lyon, France2016Google Scholar Although complex, the classification of renal cell tumors is important diagnostically and prognostically.