Abstract
Renal transplantation increases the probability of malignant tumors by about 2–4-fold overall with a much higher rate for renal epithelial malignancy. Renal tumors in renal transplant recipients are commonly conventional clear cell or papillary renal cell carcinoma. Clear cell papillary renal cell carcinoma is a recently described unique renal epithelial neoplasm with scant eosinophilic or moderate amount of clear cytoplasm and pyknotic small nuclei oriented commonly toward the apical surfaces. No such tumor has been reported in renal transplant recipients. In this paper, we describe a clear cell papillary renal cell carcinoma involving bilateral native kidneys in a patient who had received a renal transplant 2 years earlier. Clear cell papillary renal cell carcinoma commonly presents with low pathologic stage and lower Fuhrman grade and is clinically indolent. Additional cases are needed to evaluate the clinical behavior of this type of tumor in renal transplant recipients.
Highlights
Renal transplantation has greatly improved the lives of the patients with end-stage renal disease; their life expectancies are still not at par with general population
We described a renal transplant recipient with multiple cystic clear cell papillary renal cell carcinomas in both native kidneys
The patient was alive without recurrence of carcinoma 21 months status after surgery
Summary
Renal transplantation has greatly improved the lives of the patients with end-stage renal disease; their life expectancies are still not at par with general population. Clear cell papillary renal cell carcinoma (CCPRCC) is a recently described low-grade renal cell carcinoma [4,5,6,7,8,9]. Aydin et al studied gain of chromosome 7 or 17 in such tumors and found only low copy number of such chromosomal changes in 1 out of 10 cases [4]. This unique type of tumor has been described in kidneys with [9] or without [5] end-stage renal diseases. We described a renal transplant recipient with multiple cystic clear cell papillary renal cell carcinomas in both native kidneys
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