CLEAR CELL ODONTOGENIC CARCINOMA: A RARE CASE REPORT

Abstract

Clear cell odontogenic carcinoma (CCOC) is a rare malignant neoplastic process originating from the odontogenic epithelium presenting high aggressive potential. The patient, a 45-year-old male, was referred to an oral and maxillofacial surgery and traumatology referral service, reporting painful symptoms after a local anterior mandible region fracture. A histopathologic examination revealed epithelial neoplasia fragments characterized by cell proliferation in islands, cords, nests, and, occasionally, cystic spaces. The proliferating cells were pleomorphic, with a markedly clear cytoplasm. An immunohistochemical analysis was then performed, and a strong immunohistochemical reaction to CK14 and CK19 antibodies was detected for the neoplastic epithelial cells. Immunostaining was consistent with a neoplastic process of odontogenic origin. The established diagnosis was, thus, determined as CCOC. The patient was then referred to a cancer treatment reference service to undergo surgical treatment. The patient is currently in regular follow-up, without any clinical-radiographic signs of recurrence. Clear cell odontogenic carcinoma (CCOC) is a rare malignant neoplastic process originating from the odontogenic epithelium presenting high aggressive potential. The patient, a 45-year-old male, was referred to an oral and maxillofacial surgery and traumatology referral service, reporting painful symptoms after a local anterior mandible region fracture. A histopathologic examination revealed epithelial neoplasia fragments characterized by cell proliferation in islands, cords, nests, and, occasionally, cystic spaces. The proliferating cells were pleomorphic, with a markedly clear cytoplasm. An immunohistochemical analysis was then performed, and a strong immunohistochemical reaction to CK14 and CK19 antibodies was detected for the neoplastic epithelial cells. Immunostaining was consistent with a neoplastic process of odontogenic origin. The established diagnosis was, thus, determined as CCOC. The patient was then referred to a cancer treatment reference service to undergo surgical treatment. The patient is currently in regular follow-up, without any clinical-radiographic signs of recurrence.