Clear Cell Chondrosarcoma of Bone

Khalid S Ayoub,Simon R Carter,David C Mangham,Roger M Tillman,A M Davies,Robert J Grimer

doi:10.1080/13577149977749

Khalid S Ayoub, Simon R Carter + Show 4 more

Open Access

https://doi.org/10.1080/13577149977749

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Journal: Sarcoma	Publication Date: Jan 1, 1999
Citations: 31	License type: CC BY 3.0

Affiliation: Royal Orthopaedic Hospital

Abstract

Purpose. Clear cell chondrosarcoma is a rare variant of chondrosarcoma. Six cases are herein reported. Subjects. We have treated six patients with clear cell chondrosarcoma in the past 28 years, representing 1.6% of all chondrosarcomas seen in this time period. Results and Discussion. Half the patients had been initially underdiagnosed and inappropriately treated. Conclusions. Our results and our review of the literature highlight the fact that inadequate initial treatment leads to a high rate of both local recurrence and metastasis whilst wide initial excision is usually curative.

Highlights

Clear cell chondrosarcoma is a very rare malignant bone tum our. It was initially described by U nni et al in 1976,1 and was calledC lear-cell Variant of Chondrosarcoma’
We have reviewed our experience in treating clear cell chondrosarcoma at the Royal Orthopaedic Hospital, Birmingham, with the advantage of modern methods of diagnostic imaging and lim b-salva ge surgical techniques
We have undertaken a retrospective review of all patients with clear cell chondrosarcoma treated by the Royal Orthopaedic Hospital Oncology Service, Birmingham, UK

Summary

Introduction

Clear cell chondrosarcoma is a very rare malignant bone tum our. It was initially described by U nni et al in 1976,1 and was calledC lear-cell Variant of Chondrosarcoma’. Because of it’s rarity this lesion is still being confused with benign or more malignant bone tumours, both radiologically and histologically. We have reviewed our experience in treating clear cell chondrosarcoma at the Royal Orthopaedic Hospital, Birmingham, with the advantage of modern methods of diagnostic imaging and lim b-salva ge surgical techniques. All the tum ours were situated in the epiphyseo-metaphyseal area of the long bones.The most common radiographic features were; an expansile radiolucent bony lesion, absence of any periosteal reaction and absence of soft tissue mass (Fig. 1). O n T1-weighted im ages, the lesion showed relatively homogeneous low to interm ediate signal intensity, and heterogeneous high signal intensity on T2-weighted images (Fig. 2)

Patients and methods

Findings

No of patients with inadequate treatmentb