Abstract

Background: Clear cell carcinoma of the ovary (CCCO) shows unique clinical features. There is a remarkable difference in incidence among different ethnic populations. The reasons for these differences in incidence around the world are not known. Aim and objectives: To evaluate the clinical characteristics of patients with CCCO and to determine the impact of the stage of the disease and the extent of surgery on the prognosis of those patients. Materials and methods: A retrospective analysis of the cases of clear cell carcinoma of the ovary that were operated in the regional cancer centre, Cuttack, from January 2009 to December 2018, was performed to evaluate the clinical characteristics and prognostic factors of the patients. Results: During this study period, the incidence of CCCO was found to be 1.92%. The most common age group was 40–50 years (mean age of 44.7 years). The most common modes of presentation were abdominal distention and pain in the abdomen. Most of the cases in this study belonged to stage III C (65%), making it the most common stage in this group. 20% of the patients within the study group were nulliparous and 35% were menopausal in status.40% of the tumours were >15 cm in size. Almost 28% were lymph node positive. None in stage I had positive lymph nodes. All the cases in stage III were positive for lymph nodes. So, in stage III, 38.5% were positive for lymph nodes. 17/20 had some form of chemotherapy, of which 45% had NACT. Survival curves differ significantly between the early and advanced stages of the disease. A trend of survival benefit is seen with complete cytoreduction. Conclusion: There is a need for data regarding the incidence and specific clinicopathologic behaviour of clear cell carcinoma of the ovary in the Indian population. This is an attempt to compile the data from a single tertiary institute in eastern India over the past 10 years. This is a rare tumour and the chances of missing data are well accepted. The survival advantage of early-stage-diagnosed patients over late-stage patients is tremendous and hard to ignore. Combining the fact that clear cell carcinomas are associated with precancerous lesions like atypical endometriosis and atypical adenofibroma, there may be scope for screening. The mutational changes leading to malignancy in these precancerous lesions also need to be refined. As stated, complete cytoreduction is the key to survival advantage and the need for referral to a centre with proper expertise for the same needs to be emphasized.

Highlights

  • Clear cell carcinoma (CCC) was initially termed "mesonerhroma ovarii’ in 1939.[1]

  • Considering that endometriosis leads to clear cell carcinomas, younger age is expected at presentation

  • Ovarian CCC typically manifests as a pelvic mass.Recent reports involving large institutional cohorts compared low-stage to high-stage ovarian cancers (I/II vs. III/IV) and showed that 57–81% of CCC were diagnosed at stage I/II. [8,9] In a retrospective review done in Japan on more than 600 patients over 10 years, 49% of CCC were stage I compared to 17% of SC,[9] and in SEER data, 56% of CCC were stage I compared to 19% for SC

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Summary

Introduction

Clear cell carcinoma (CCC) was initially termed "mesonerhroma ovarii’ in 1939.[1]. Since 1973, it has been strictly defined by the World Health Organization as lesions characterised by clear cells growing in solid/tubular, or glandularInternational Journal of Medical Science and Clinical Invention, vol 08, Issue 11, November 2021Bhagyalaxmi Nayak et al / Clear Cell Carcinoma Of The Ovary.patterns as well as hobnail cells.[2]. [3] Overall, it is noted that CCCO is quite rare in western countries but not so uncommon in Asia The reasons for these differences in incidence around the world are not known.[4] In this study, we aimed to evaluate the clinical characteristics of patients with CCC of the ovary and to determine the impact of the stage of the disease and the extent of surgery on the prognosis of those patients. Clear cell carcinoma of the ovary (CCCO) shows unique clinical features. Conclusion: There is a need for data regarding the incidence and specific clinicopathologic behaviour of clear cell carcinoma of the ovary in the Indian population This is an attempt to compile the data from a single tertiary institute in eastern India over the past 10 years. Complete cytoreduction is the key to survival advantage and the need for referral to a centre with proper expertise for the same needs to be emphasized

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