Abstract
BackgroundMalignant transformation of endometriosis associated with episiotomy scar is a rare event, especially histological type of clear cell adenocarcinoma. There are only three clear cell carcinoma in episiotomy scar reported, no standard treatment established.Case presentationA 36-year-old woman presented with a two-month history of painless but puritic perineal lump which she noticed was gradually enlarging. She had undergone surgical excision of a mass in the episiotomy scar 9 year ago and resequently histological type of endometriosis. Physical examination revealed a 10 × 5 cm soft, purple scar which is closely related to the apex of the episiotomy.We underwent a local excision of the mass for a biopsy . The second surgery performed after one cycle of paclitaxel and cisplatin (TP) to permit clearance of tumor while preserving normal vaginal function.Pathological result was clear cell adenocarcinoma. Two cycles of TP adjuvant chemotherapy were administrated after surgery.ConclusionsWe report a case of primary clear cell carcinoma developing within a previous episiotomy scar in a patient with a history of endometriosis, along with a review of the literature. Accumulation of management data on these rare tumors and Long-term follow-up of such patients is therefore important.
Highlights
We report a case of primary clear cell carcinoma developing within a previous episiotomy scar in a patient with a history of endometriosis, along with a review of the literature
Malignant transformation of endometriosis associated with episiotomy scar is a rare event, especially histological type of clear cell adenocarcinoma
Case presentation A 36-year-old woman presented with a two-month history of painless but puritic perineal lump which she noticed was gradually enlarging
Summary
We report a case of clear cell carcinoma arising from episiotomy scar. There are only three clear cell carcinoma in episiotomy scar reported, no standard treatment established. Abdominal wall endometriosis: a surgeon’s perspective and review of 445 cases. The association between endometriosis and ovarian cancer: A review of histological,genetic and molecular alterations. ARID1A Mutations and PI3K/AKT Pathway Alterations in Endometriosis and EndometriosisAssociated Ovarian Carcinomas. Benoit L, Arnould L, Cheynel N, Diane B, Causeret S, Machado A, et al Malignant extraovarian endometriosis: A review. LH participated in drafting the manuscript and performed literature review. All authors read and approved the final manuscript
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