Abstract
A 63-year-old man with clear-cell acanthoma of the vermilion mucosa of the lower lip is reported. The 143 previously documented cases, including two on the lip, have all been on the skin. The clinical and histopathologic features of clear-cell acanthoma tend to favor a benign epidermal neoplasm. Until its exact nature is known, it is suggested that clear-cell acanthoma be considered a benign localized squamous-cell lesion in which an intracellular enzyme defect has resulted in the prominent accumulation of glycogen and enlargement of the cell.
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