Cálculo de prevalencia y riesgo atribuible de los factores de riesgo relacionados con la persistencia o recidiva de neoplasia cervical intraepitelial (CIN)

Abstract

The present study aimed to determine the prevalence of risk factors associated with treatment failure at diagnosis of cervical intraepithelial neoplasia (CIN), identify the increased risk posed by treatment failure, and define the prototype of high-risk patients with persistent or recurrent CIN with a view to characterizing the percentage of the population with treatment failure.The most prevalent demographic and environmental risk factors in our population were the presence of high-risk human papillomavirus (HR-HPV)-DNA, followed by smoking, multiparity, a history of hormonal contraception, and HIV-immunosuppression.When performing colposcopic study, the following characteristics were found: 53.30% of the patients had multiple lesions, size was greater than 2cm in 30.00% of patients and major changes were found in the area of transformation in 49.51% of the total.After completing the study, the results were as follows: cure was achieved in more than 90%, persistence was found in 4.35% and recurrence occurred in 1.8%. These results indicate that there are common risk factors associated with treatment failure, including the persistence of HR-HPV after treatment and poor immune response. The remaining factors were unevenly distributed among patients with CIN-I and CIN-II-III, suggesting that these patients constitute two distinct populations with specific risk factors.