Abstract
Clavulanic acid (CA), a metabolite of Streptomyces clavuligerus , is a potent β-lactamase inhibitor. In this study, polyurethane foam (PUF) was used as inert solid support to produce clavulanic acid by solid state fermentation (SSF). Maximal CA yield of 263 µg/ml was obtained at pH 6.5, incubation temperature 29°C, 10 ml medium per 3 g PUF, 0.015% added glycerol, 2% added lithium chloride (LiCl), and 2 g/L added ornithine. Under the same conditions, the yield of CA produced by SSF on PUF is apparently higher than that by submerged fermentation (SMF). In addition, CA produced by using this method is of higher purity and easier to be extracted. Citation: Wang, H. and Chen, H. (2016). Clavulanic Acid Production by Streptomyces clavuligerus using Solid State Fermentation on Polyurethane Foam. Trends in Renewable Energy, 2(1), 2-12. DOI: 10.17737/tre.2016.2.1.0018
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
