Abstract

Two new dimeric carbazole alkaloids, clausenawallines A and B, were isolated from the roots of Clausena wallichii. Their structures were elucidated by spectroscopic methods. Clausenawalline A was evaluated for its biological activities [anti-malaria (IC50 2.46μg/mL), anti-TB (MIC 12.50μg/mL)] and cytotoxicity against three human cancer cell lines [KB (IC50 7.87μg/mL), MCF7 (IC50 25.43μg/mL), and NCI-H187 (IC50 10.97μg/mL)].

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