Abstract
A new cyclic octapeptide, named clausenain B, was isolated by a multi-step chromatography procedure from Clausena anisum-olens. Its structure was established as cyclo(-Phe¹-Ser-Leu¹-Phe²-Phe4-Gly-Leu²-Phe³-) (1) based on extensive spectroscopic studies and chemical evidence. Clausenain B (1) is a phenylalanine-rich cyclic octapeptide.
Highlights
Plants of the Rutaceae family are widely distributed in the South of China.[1]
A small number of cyclopeptides have been isolated from the plants of Rutaceae.[8]
In order to search for other natural cyclic peptides from the genus Clausena, we further investigated the EtOH extract of Clausena anisum-olens
Summary
Plants of the Rutaceae family are widely distributed in the South of China.[1]. Within this family, Clausena are shrubs widely distributed in South and Southeast Asia and many species are used in Chinese folk medicine for various indications.[1]. Chemical studies of this extract led to the isolation of a new cyclic peptide named clausenain B (1) from the EtOAc portion of whole plants. The 1H NMR signals of amino acid residues, especially the signals of NH and α-H, heavily overlapped at room temperature.
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