Abstract
The clastogenic and mutagenic effects of the hexavalent chromium compound K 2CrO 4 in lacZ transgenic mice (Muta TMMouse) were investigated. Male Muta TMmice were administered an intraperitoneal dose of 40 mg/kg of K 2CrO 4 once on each of 2 consecutive days. The K 2CrO 4 induced a significant increase in the peripheral blood micronucleated reticulocyte count. Also, K 2CrO 4 induced a statistically significant increase in mutant frequency in the liver but not in the bone marrow on day 7 after the second treatment. The reason for the failure to increase the mutant frequency in the bone marrow may have been the rapid cell turnover rate there. The mutation induced by K 2CrO 4 in the bone marrow may have occurred in more differentiated cells than stem cells, and the rapid proliferative activity may have caused a rapid decrease in mutated cells by day 7. Further study with a sampling point earlier than day 7 is needed. The results obtained in the present study indicate that K 2CrO 4 has clastogenic and mutagenic potential in vivo.
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