Abstract
The genotoxic effect of passive inhalation of sidestream cigarette smoke on bone marrow polychromatic erythrocytes was studied using male NMRI mice. The animals were placed in individual 145.2-dm 3 glass chambers resembling a room provided with normal air flow. They were exposed to the sidestream smoke of a commercial brand of cigarettes smoked by a smoking machine under standard conditions. Increased formation of micronuclei within polychromatic erythrocytes (PCEs) of femoral bone marrow 30 h after passive smoking was regarded as being due to the clastogenic effect of the smoke. Passive inhalation of the diluted sidestream smoke of a single cigarette resulted in a significant increase ( P < 0.01) in the frequency of micronucleated PCEs. This clastogenic activity was found to be dose-dependent.
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