Classifying Causality of an Adverse Drug Reaction: Naranjo Algorithm

Abstract

The Naranjo adverse drug reaction likelihood scale was elaborated to assist standardizes apprehensiveness of causality for entire adverse drug reaction.). Adverse drug reaction is an unpleasant or detrimental reaction proficiency pursuing the administration of a medication or combination of medications under usual circumstances of usage, which is doubted to be affiliated to the medicine. Causality delineated as the likelihood that a specific medication is accountable for a secluded consequence or adverse drug reaction. Certain (doubtful) causality if the total score is zero or lower. Possible causality delineated as if the total score is one to four. When a medical circumstances happens with a consequent time resultant to medication uptake, but which could be described by coincident malady or distinctive medication uptake. Probable or likely causality delineated as if the total score is five to eight. When a medical circumstance happens with a well-founded time consequence to medication uptake and is questionably to be owing to every coincident infirmity or disparate medication uptake. When a medical circumstances enclosing laboratory parameters anomaly happens in a presumptive time consociated to medication administered to the patients and cannot be described by coincident malady or distinctive medications or pharmaceutical products; administer of the mediation redundantly antecedents a connate response or reaction to discontinuation presumptive (a medicines qualities consequences, and relating to the study of malady).