Classifying alzheimer's disease from sMRI data using a hybrid deep learning approaches

Abstract

The chance of developing "Alzheimer's Disease (AD)" increases every 5 years after 65 years of age, making it a particularly common form of neurodegenerative disorder among the older population. The use of "Magnetic Resonance Imaging (MRI)" to diagnose AD has grown in popularity in recent years. A further benefit of MRI is that it provides excellent contrast and exquisite structural detail. As a result, some studies have used biological markers backed by "structural MRI (sMRI)" to separate AD populations, which indicate differences in brain tissue size and degradation of the nervous system. The lack of properly segmented regions and essential features by the existing models might affect classification accuracy for AD. The categorization of AD in this study is based on sMRI. In this research, the hybrid Deep-Learning Models "SegNet and ResNet (SegResNet)" have been proposed for segmentation, feature extraction, and to classify the AD. SegNet network is used to identify and segment specific brain areas. Edges and circles are the SegNet's first levels, whereas the deeper layers acquire more nuanced and useful features. SegNet's last deconvolution layer produces a wide range of segmented images linked to the 3 categorization labels "Cognitive Normal (CN)", "Mild Cognitive Impairment (MCI)", and "AD" which the machine has earlier found out. To increase classification performance, the attributes of each segmented sMRI image serve as strong features of the labels. To enhance the feature information used for classification, a feature vector is built by combining the values of the pixel intensity of the segmented sMRI images. ResNet-101 classifiers are then used for characterizing vectors to identify the presence or absence of AD or MCI in each sMRI image. In terms of detection and classification accuracy, the proposed SegResNet Model is superior to the existing KNN, EFKNN, AANFIS, and ACS approaches