Classification of membrane protein using Tetra Peptide Pattern

Abstract

Membrane proteins play an important role in the life activities of organisms. The mechanism of cell structures and biological activities can be identified only by knowing the functional types of membrane proteins which accelerate the process. Therefore, it is greatly necessary to build up computational approaches for timely and accurate prediction of the functional types of membrane protein. The proposed method analyzes the structure of the membrane proteins using novel Tetra Peptide Pattern (TPP)-based feature extraction technique. A frequency occurrence matrix is created from which a feature vector is formed. This feature vector captures the pattern among amino acids in a membrane protein sequence. The feature vector is reduced in the dimension using General Kernel-based Supervised Principal Component Analysis (GKSPCA). Stacked Restricted Boltzmann Machines (RBM) in Deep Belief Network (DBN) is used for classification. The RBM is the building block of Deep Belief Network. The proposed method achieves good results on two datasets. The performance of the proposed method was analyzed using Accuracy, Specificity, Sensitivity and Mathew's correlation coefficient. The proposed method achieves good results when compared to other state-of-the-art techniques.