Abstract
Degenerative disc disease is the most common cause of low back pain. Intervertebral disc abnormalities are commonly evaluated by magnetic resonance imaging (MRI), and Pfirrmann’s system involves the use of T2-weighted images (T2WI) to classify disc degeneration. However, as this classification is based on visual evaluation, it is not possible to quantify degeneration using this method. The present study was performed to establish an MRI-based intervertebral disc classification system using diffusional kurtosis imaging (DKI), to quantify intervertebral disc water content according to the Pfirrmann classification. Sagittal mean diffusional kurtosis (MK) mapping was performed for the L3/4, L4/5, and L5/S1 intervertebral discs in 32 patients (15 female, 17 male; age range, 24 - 82 years; mean age, 57.7 years). The degree of disc degeneration was assessed in the midsagittal section on T2WI according to the Pfirrmann classification (grade I - V). The relationships between MK values, which are correlated with intervertebral disc composition changes, and grade of degeneration determined using the Pfirrmann classification were analyzed. The MK values tended to decrease with increasing grade of degeneration, and differed significantly between grades I and IV, but not between grade IV and V (P < 0.05, Mann-Whitney U test). DKI is an effective means of detecting the early stages of disc degeneration. Therefore, DKI may be a useful diagnostic tool for quantitative assessment of intervertebral disc degeneration.
Highlights
Low back pain is one of the most common causes of disability in the working-age population, and has a number of known causes [1] [2], the most common of which is degenerative disc disease [3] [4]
Sagittal mean diffusional kurtosis (MK) mapping was performed for the L3/4, L4/5, and L5/S1 intervertebral discs in 32 patients (15 female, 17 male; age range, 24 - 82 years; mean age, 57.7 years)
Sagittal MK mapping was performed for the L3/4, L4/5, and L5/S1 intervertebral discs in 32 patients, total 96 discs
Summary
Low back pain is one of the most common causes of disability in the working-age population, and has a number of known causes [1] [2], the most common of which is degenerative disc disease [3] [4]. MRI is a useful tool to quantify degenerative intervertebral discs [8] [9]. Pfirrmann et al developed a system for classifying the degree of disc degeneration based on T2WI findings [10] [11] [12] As this classification is based on visual evaluation, it is not possible to quantify the degree of degeneration using this method. As the MK value is a quantitative parameter that varies with collagen and water contents in cartilage and intervertebral discs, it may be useful for characterizing the etiology of lower back pain and disc degeneration [13]. The present study was performed to establish an intervertebral disc MRI classification system using diffusional kurtosis imaging (DKI), with an emphasis on the evaluation of early intervertebral disc degeneration, by quantifying disc water contents according to the Pfirrmann classification
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