Classification of Interstitial lung disease patterns in CT images using convolutional neural network

Abstract

Abstract-Automated tissue characterization is one of the most crucial components of a computer aided diagnosis (CAD) system for interstitial lung diseases (ILDs). Although much research has been conducted in this field, the problem remains challenging. Deep learning techniques have recently achieved impressive results in a variety of computer vision problems, raising expectations that they might be applied in other domains, such as medical image analysis. In this paper, we propose and evaluate a convolutional neural network (CNN), designed for the classification of ILD patterns. The proposed network consists of 5 convolutional layers with 2x2 kernels and LeakyReLU activations, followed by average pooling with size equal to the size of the final feature maps and three dense layers. The last dense layer has 7 outputs, equivalent to the classes considered: healthy, ground glass opacity (GGO), micro nodules, consolidation, reticulation, honeycombing and a combination of GGO/reticulation. To train and evaluate the CNN, we used a dataset of 1469 image patches, derived by 20 CT scans from different scanners and hospitals. To the best of our knowledge, this is the first deep CNN designed for the specific problem. The classification performance demonstrated the potential of CNNs in analysing lung patterns. Key Words: Micro nodules, honeycombing, image analysis, classification