Abstract
No abstract available.
Highlights
HIV infection is a multisystem disease characterised by progressive immunodeficiency and increasing susceptibility to common and opportunistic pathogens
Decisions to initiate antiretroviral therapy (ART) or to change therapy because of regimen failure are based on an understanding of disease progression
The classification system allows for surveillance, facilitating planning by ministries of health for adequate resources and equitable access to care
Summary
As children are growing and developing, many clinical manifestations may be unique to children. Both the immunological system and organs grow and develop in children but are static in adults. The CD4 percentage stays relatively constant, but there is a decline in CD4+ T-cell numbers as children mature. CD4 cells may be functionally immature, most graphically illustrated by the finding of a high 14 november 2005
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