Abstract
ABSTRACTIntroduction: Folliculotropic mycosis fungoides (FMF) is a cutaneous T cell lymphoma that is recognized as a distinct variant of mycosis fungoides (MF) due to its unique clinicopathologic features and its more aggressive disease course as compared to classic MF. Recent studies distinguished an indolent (early stage FMF) and a more aggressive (advanced stage FMF) subgroup, that require a different therapeutic approach.Areas covered: This review provides an overview of the evolving concepts and recent developments in FMF and summarizes various treatment options for early and advanced stages of FMF including skin-directed therapies, immunomodulating agents, HDAC inhibitors, targeted anti-CD30 therapy and the role of chemotherapy and haematological stem cell transplantation.Expert opinion: Recently defined prognostic subgroups show that early stage FMF patients have an indolent disease course and may benefit very well from skin-directed therapies, also used in early stage classic MF. Advanced skin limited FMF patients benefit most from radiotherapy based treatment modalities. Systemic chemotherapy is reserved for patients with extracutaneous dissemination or progressive disease that cannot be controlled with skin-directed or immunomodulating therapies.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.