Classification and Progression Based on CFS-GA and C5.0 Boost Decision Tree of TCM Zheng in Chronic Hepatitis B

Xiao Yu Chen,Li Zhuang Ma,Yiyang Hu,Na Chu,Min Zhou

doi:10.1155/2013/695937

Abstract

Chronic hepatitis B (CHB) is a serious public health problem, and Traditional Chinese Medicine (TCM) plays an important role in the control and treatment for CHB. In the treatment of TCM, zheng discrimination is the most important step. In this paper, an approach based on CFS-GA (Correlation based Feature Selection and Genetic Algorithm) and C5.0 boost decision tree is used for zheng classification and progression in the TCM treatment of CHB. The CFS-GA performs better than the typical method of CFS. By CFS-GA, the acquired attribute subset is classified by C5.0 boost decision tree for TCM zheng classification of CHB, and C5.0 decision tree outperforms two typical decision trees of NBTree and REPTree on CFS-GA, CFS, and nonselection in comparison. Based on the critical indicators from C5.0 decision tree, important lab indicators in zheng progression are obtained by the method of stepwise discriminant analysis for expressing TCM zhengs in CHB, and alterations of the important indicators are also analyzed in zheng progression. In conclusion, all the three decision trees perform better on CFS-GA than on CFS and nonselection, and C5.0 decision tree outperforms the two typical decision trees both on attribute selection and nonselection.

Highlights

With a history of 2000 to 3000 years, Traditional Chinese Medicine (TCM) has formed a unique system to diagnose and cure illness
An approach based on CFS-GA (Correlation based Feature Selection and Genetic Algorithm) and C5.0 boost decision tree is used for zheng classi cation and progression in the TCM treatment of Chronic hepatitis B (CHB). e CFS-GA performs better than the typical method of CFS
Based on the critical indicators from C5.0 decision tree, important lab indicators in zheng progression are obtained by the method of stepwise discriminant analysis for expressing TCM zhengs in CHB, and alterations of the important indicators are analyzed in zheng progression

Summary

Introduction

With a history of 2000 to 3000 years, Traditional Chinese Medicine (TCM) has formed a unique system to diagnose and cure illness. In TCM, the treatment of illness is based primarily on the diagnosis and differentiation of syndromes [1]. Syndrome differentiation is the method of recognizing and diagnosing diseases or body imbalances by analyzing clinical information based on TCM theories and the doctor’s experience [3]. TCM has formed a systematized methodology of diagnosis and treatment based on the rich practical knowledge and experience of Chinese people in struggling against diseases. In 1992 and 2002 [4, 5], the Medicine Committee for Liver Disease of the Chinese Medicine Institute and the State Drug Administration formulated the trial viral hepatitis TCM standards and the Chinese medical clinical research guidelines for CHB, respectively, but it still lacks an objective standard for the speci c TCM syndromes of CHB.

Methods

Results

Conclusion