Abstract
BackgroundCardiovascular disease (CVD) constitutes a major public health problem in China and worldwide. We aimed to examine classical risk factors and their magnitudes for CVD in a Chinese cohort with over 20 years follow-up.MethodsA cohort of 5092 male steelworkers recruited from 1974 to 1980 in Beijing of China was followed up for an average of 20.84 years. Cox proportional-hazards regression model were used to evaluate the risk of developing a first CVD event in the study participants who were free of CVD at the baseline.ResultsThe multivariable-adjusted hazard ratio (HR) associated with every 20 mmHg rise in systolic blood pressure (SBP) was 1.63 in this Chinese male population, which was higher than in Caucasians. Compared to non-smokers, men who smoked not less than one-pack-a-day had a HR of 2.43 (95% confidence interval [CI], 1.75-3.38). The HR (95% CI) for every 20 mg/dl increase in total serum cholesterol (TC) and for every point rise in body mass index (BMI) was 1.13 (1.04-1.23) and 1.06 (1.02-1.09), respectively.ConclusionsOur study documents that hypertension, smoking, overweight and hypercholesterolemia are major conventional risk factors of CVD in Chinese male adults. Continued strengthening programs for prevention and intervention on these risk factors are needed to reduce the incidence of CVD in China.
Highlights
Cardiovascular disease (CVD) constitutes a major public health problem in China and worldwide
A total of 599 deaths were reported, 240 persons died of CVD, 194 persons died of neoplasm and 165 persons died of other disease and injury
Compared to non-smokers, the multivariable adjusted hazard ratio (HR) of CVD was 2.43 for men who smoke more than or equal to one-pack-a-day
Summary
Cardiovascular disease (CVD) constitutes a major public health problem in China and worldwide. We aimed to examine classical risk factors and their magnitudes for CVD in a Chinese cohort with over 20 years follow-up. Cardiovascular disease (CVD) constitutes a major public health problem in China [1] and worldwide [2]. Classical risk factors for coronary heart disease (CHD) and stroke have been identified [3,4], such as high blood pressure, tobacco smoking, hypercholesterolemia, obesity and age. The roles of major cardiovascular risk factors in the development of CHD or stroke are well established in Western populations. While for Chinese, data are less extensive, especially lack of over twenty years prospective cohort study to investigate the magnitude of classical risk factors for CVD. Compared with Western populations, the incidence and mortality rates of
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