Classical description of activated conformational processes in molecular systems coupled to solvent degrees of freedom

Abstract

Extended Fokker-Planck (FP) equations are generalized stochastic equations which describe the evolution of a set of coordinates, loosely referred to as solute, coupled with a relevant set of solvent variables. They are useful for the analysis of molecular dynamics in liquids, when a time-scale separation between probe motions and relaxation times of interactions with surroundings particles cannot be performed, because of persistence of slowly fluctuating components. In this article, we focus attention on a model system, made up of an angular coordinate and its conjugate momentum, submitted to a bistable potential, and coupled to a dissipative harmonic mode, to investigate the influence of polar solvents on reactive dynamics. The results are appropriate to describe dielectric effects, solvent-controlled conformational changes involving charge transfer which occur in photophysical processes, and the dynamic Stokes shifts observed in time-resolved fluorescence experiments. © 1996 John Wiley & Sons, Inc.