Abstract
It was shown by the methods of enzymic radioiodination, immunoprecipitation, and electrophoresis in sodium dodecylsulfate-polyacrylamide gels that splenic lymphocytes of normal rats carry on their surface immunoglobulins of two main classes: monomeric IgM (IgMS) and Ig(H2L2), the heavy chains of which are a little smaller than μ chains and differ from them in their antigenic properties. The class of cell surface Ig thus revealed is evidently equivalent to human IgD and to the IgD-like protein of the cytoplasmic membrane of mouse lymphocytes. The presence of small quantities of IgG on the surface of lymphocytes can be explained both by its cytophilic properties and by the immunological state of the experimental animals.
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