Class Regular–Increased– and Class Iso–Toxicity, the two clearly defined and recognisable forms of the phenomenon. A developed Köln–Model (Hydractinia echinata Test–System. V.) study

Abstract

According to the currently developed Köln–Model based on Hydractinia echinata Test–System (HeTS), the methodical toxicity investigations conducted with amphiphilic and non–amphiphilic singular derivatives with homo– and heteronomous segmentation from 20 different classes, reveals that the effectiveness noted M (mol/L) are characteristic for the Aromatic Basis of Toxicity (ABT) model, for the Class Regular–Increased Toxicity (CRIT) and for Class Iso–Toxicity (CIT), respectively. The phenomenon of toxicity is the result of monovalent interaction between the larval cellular receptor (R) of the marine colonial hydroid H. echinata organism and the xenobiotic substrate (SbX) with the molecular aggregate transitional–complex (RSbX) formation and the information–signal generation (SI), according to the Dual Causality Principle that biological phenomena are simultaneously determined by genetic programs and physics laws. The SI consists of chemical (SIch) and electromagnetic (SIem) components, and is directly responsible for the simultaneous onset of the metamorphosis quantified by the M toxicity values and the metabolizing process of the SbX, with the formation of the reaction products (P). The CRIT, respectively CIT approach was also successfully applied to published data obtained with the ciliate protozoan Tetrahymena pyriformis (T. pyriformis), the freshwater fish Pimephales promelas (P. promelas), the freshwater crustacean Daphnia magna (D. magna) and the marine bacterium Vibrio fischeri (name Aliivibrio fischeri) test–systems (TS’s).