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Abstract
Class 1A agents share the electrophysiologic property of slmuing of Vmax of phase 0 of the action potential and moderate prolongation of the action potential duration and refractoriness. Their electrocardiographic effect in therapeutic doses is to prolong the QTc. interval due to prolongation of the JTc interval. The PR and QRS intervals are not prolonged in therapeutic doses. This group of agents contains the standard antiarrhythmic agents released prior to 1984. The older drugs in this group wilt be reviewed only briefly in this report. Their effect on suppression of ventricular ectopic depolarizations will be reviewed for comparison with the newer agents.
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