Abstract
The emergence of a reaction cycle in a mixture of reacting molecules may require naturalized regulation of the constituent material elements. One source of naturalized regulation could be sought in updating the constituent elements through exchanging with those available from the outside under the conditions of unidirectional heat flow. One physical vehicle for implementing constant material exchange could be a durable reaction cycle serving as a necessary precursor to the phenomenon called life. Each constituent element circulating around a durable reaction cycle moves causally until it comes to eventually leave the cycle. At the same time, the circulation is also retrocausal in letting the reaction flow in the downstream pull in and being cohesive to those reactants in the immediate upstream. The onset of a reaction cycle as a precursor to the origins of life must have corresponded to a unique historical event taking advantage of the likelihood of retrocausal cohesion propagating backward along the reaction sequence. Physical underpinning of biology may be found in the operation of retrocausal cohesion.
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