Claisen-Schmidt, aza-Michael, cyclization via cascade strategy toward microwave promoted synthesis of imidazo[2,1-b]quinazolines

Abstract

Imidazole blended quinazolines are having a wide run of potential applications in synthetic field. In this current investigation, we reported a modern synthesis with the help of non-conventional energy. Optimization parameters have been stabilized utilizing RSM (Response Surface Method) as well as Taguchi models. The yield obtained from the proposed protocol is significantly higher compared to other routine strategies. The products were explored by implies of 1H, 13C-NMR and HR-MS investigation. Interestingly, cyclization & aromatization has been influenced by KOH in a greater extent. It is critical that the imidazo[1,2-b]quinazolines show intense fluorescence emission, significant stokes shift, and high quantum yield.