Claisen ortho ester rearrangement with trimethyl β-(methoxy)orthopropionate: a thermally stable synthon for the preparation of methyl α-substituted acrylates

Abstract

Trimethyl β-(methoxy)orthopropionate, a compound which is thermally stable at 190 °C for prolonged times, may be utilized as a synthon for the preparation of methyl α-substituted acrylates via Claisen ortho ester rearrangement with allylic alcohols followed by β-elimination of methanol with base.