Abstract
The aim of this study was to assess the effectiveness of cladribine treatments in a population of patients with refractory myasthenia gravis (MG). In a prospective open-label study of cladribine in refractory MG, 13 patients received cladribine at baseline with repetitive cycles driven by clinical response. A Myasthenia Gravis Composite (MGC) score was obtained and a standard dose of steroids was administered. A total of 11 patients achieved significant clinical improvement in MGC score during their therapy. The mean MGC score declined from 15.1 to 6.3 points within 4months of observation. The dosage of prednisolone declined from 9.5 to 1.9mg. None of the patients required intravenous immunoglobulin or plasma exchange treatments and no adverse events occurred in the study period. Cladribine seems to be a safe and effective emergency therapy in a population of patients with refractory MG.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
