Citrus aurantifolia (Christm.) swingle extract ameliorates oxidative stress, dyslipidemia, and inflammation in galactose-induced aging in female rats

Abstract

Aging is linked with pathological conditions that can be managed with diet. Citrus, which belongs to the family Rutaceae, are used for several medicinal purposes. This study evaluated the modulatory effect of Citrus aurantifolia (lime) on some pathological conditions associated with aging. Twenty female albino rats were randomly divided into four groups: Control (water), the model (D-galactose), the treatment group (D-galactose and lime), and the standard (D-galactose and quercetin). Superoxide dismutase (SOD), catalase (CAT), and lipid profile were monitored in the heart, liver, kidney, and the brain. Tumor necrosis factor (TNF), Interleukins (IL-6 and IL-10), and reproductive hormones were analyzed in the blood using the ELISA kits. CAT increased in the treated and standard groups (14.03 and 13.60 U/mg respectively) compared with the model (9.18 U/mg). There was a decrease in liver SOD, but an increase in brain and kidney SOD. The level of IL-6 was reduced in treated and standard groups compared to the model. LDL-C was reduced in the treated and standard groups while the level of HDL-C increased in the treated groups. Luteinizing hormone (LH) increased while the follicle-stimulating hormone reduced. C. aurantifolia extract ameliorates oxidative stress, inflammation, and dyslipidemia associated with aging and its processes.