Abstract
Methods We have studied the effect of rifampicin on growth of cells, with and without the nanoparticles. Further, cellular uptake of nanoparticles was studied by transmission electron microscopy. Since, permeability barrier and drug efflux are responsible for intrinsic drug resistance, we have performed accumulation and efflux studies on common efflux pump substrate ethidium bromide (EtBr) by semi automated fluorometric method in the presence and absence of nanoparticles.
Highlights
The major problem faced in current tuberculosis (TB) therapy is intrinsic drug resistance of mycobacterium
We have investigated the effect of citric acid coated magnetite nanoparticles in combination with rifampicin against a wild type strain of Mycobacterium smegmatis
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Summary
The major problem faced in current tuberculosis (TB) therapy is intrinsic drug resistance of mycobacterium. There is a need to develop ways to overcome these resistance mechanisms. We have investigated the effect of citric acid coated magnetite nanoparticles in combination with rifampicin against a wild type strain of Mycobacterium smegmatis
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