Abstract
Abstract We report the hydrothermal synthesis of uniform size (∼6 nm) oleic acid capped CoFe 2 O 4 (OA-CoFe 2 O 4 ) nanoparticles. These OA-CoFe 2 O 4 nanoparticles were initially hydrophobic and not dispersible in water which were transformed into hydrophilic nanoparticles by modifying their surface with citric acid using a rapid mechanochemical ligand exchange process, which makes CoFe 2 O 4 nanoparticles stable colloidal solution in water. The synthesized citric acid coated CoFe 2 O 4 (CA-CoFe 2 O 4 ) nanoparticles show a high enough and stable zeta potential over 120 days. CA-CoFe 2 O 4 nanoparticles exhibited high biocompatibility under in vitro cell studies. The specific absorption rate (SAR) of the CA-CoFe 2 O 4 nanoparticles was measured by induction heating studies. Upon the exposure of AC external magnetic field, the viability of cancer cells was reduced considerably, suggesting efficient potentiality of these CA-CoFe 2 O 4 nanoparticles for Magnetic Hyperthermia Applications. Present mechanochemical ligand exchange method is proposed as an efficient method for large scale production of biocompatible and water dispersible magnetic oxide nanoparticles for Magnetic Hyperthermia Applications.
Published Version
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