Abstract
As clinical trials on acne, this study aimed to assess the potential of citral in easing acne inflammation by inhibiting and unveiling the inflammatory activity of citral. For this, a total of 36 testees with high acne occurrence (age 19-23) were chosen and administered citral (0.5%, 1%) twice a day over 12 weeks. Then, the size and severity of inflammatory acne and amount of sebum production were investigated. In addition, inflammation images were analyzed. According to clinical trials, inflammation improvements were confirmed in all experimental groups (both 0.5% and 1% citral contents) (p＜0.05). When the size and shape of a pustule, which are critical indicators for in inflammation improvements, were observed, in particular, both size and shape diminished by 52% in the 1% citral group (p＜0.05). In terms of sebum production, T-zone revealed a significant decrease in the 1% citral group (p＜0.05) while U-zone showed a decrease in the 0.5% citral group (p＜0.05). According to analysis of inflammation images, considerable inflammation improvements were found in both 0.5% and 1% citral groups. After inflammation, pigmentation also improved, resulting in skin brightening. The above results confirm that citral is more effective in easing mild acne symptoms. In terms of inflammation improvements, it appears that the 1% citral group is more effective.
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