Abstract
Meeting abstracts IL-15 activates and induces the proliferation of CD8+ T cells and NK cells. ALT-803 (Altor Bioscience, Miramar, FL) is a superagonist of IL-15 consisting of 2 molecules of IL-15 N-to-D substituted at position 72, bound to 2 molecules of the sushi domain of IL-15 alpha receptor
Highlights
IL-15 activates and induces the proliferation of CD8+ T cells and NK cells
ALT-803 (Altor Bioscience, Miramar, FL) is a superagonist of IL-15 consisting of 2 molecules of IL-15 N-to-D substituted at position 72, bound to 2 molecules of the “sushi” domain of IL-15 alpha receptor and a single Fc fragment of IgG1
ALT-803 has been shown to exert superior antitumor activity and possess a longer half-life compared with unmodified IL-15 in animal models of myeloma, melanoma and bladder cancer
Summary
CITN-06: a Phase I/expansion trial of alt-803, an IL-15 superagonist, in patients with advanced melanoma. Kim Margolin1*, Hing C Wong, Chihiro Morishima, Liza Hernandez, Marc Ernstoff, Peter R Rhode, Thomas A Waldmann. From Society for Immunotherapy of Cancer 29th Annual Meeting National Harbor, MD, USA. From Society for Immunotherapy of Cancer 29th Annual Meeting National Harbor, MD, USA. 6-9 November 2014
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