Cisplatin + Vinorelbine Treatment of Recurrent or Metastatic Salivary Gland Malignancies (Rmsgm): a Final Report on 60 Cases

Abstract

ABSTRACT Aim: RMSGM are not suitable for conventional treatment. We report the clinical outcomes of 60 patients affected by RMSGM who were treated with DDP + VNB as a first- or second-line scheme. Methods: Sixty patients between 2001 and 2008, affected by RMSGM were enrolled in this cohort prospective study; they received the following first- or second-line CT, for a maximum of 6 cycles: DDP at 80 mg/m2 on d 1 + VNB at 25 mg/ m2 on d 1 and 8, at 3-wk intervals. Results: Seventy percent of the patients received DDP + VNB as the first-line CT and 30% of them received it as the second-line CT. After 5 cycles (median) of first-line DDP + VNB, 7% of the patients achieved a CR, 24% achieved a PR, 33% achieved an NC and 36% achieved a PD. After 4 cycles (median) of second-line CT, 0 patients achieved a CR, 5% achieved a PR, 33% achieved an NC and 62% achieved a PD. The median OS period was 10 months for those who received the first-line CT and 4 months for those who received the second-line CT. The best ORR (54%) and median survival were observed, during first line treatment, in adenocarcinomas, whereas undifferentiated tumours were unresponsive with a poor median survival (4.6 months). Conclusions: Adenocarcinomas show the best response and prognosis with DDP + VNB scheme that seems to be an effective and well-tolerated first-line CT for RMSGM, whereas it has only low palliative activity as a second-line CT. Disclosure: All authors have declared no conflicts of interest.