Abstract
Protective Effect of Adiantum Capillus Against Chemically Induced Oxidative Stress by CisplatinKanchan Gaikwad,Swati Dhande,Y M Joshi,Vilasrao Kadam
Highlights
Cisplatin was accidentally discovered over four decades ago, and since it has widely been used for chemotherapy (Arany and Safirstein, 2003; Wang and Lippard, 2005)
Results of the study revealed that cisplatin-injected rats showed a reduction in the relative kidney weight with an elevation in the serum kidney function and renal inflammatory mediators viz. myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-α), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) and interlukin-1β (IL-1β)
Simvastatin (10 mg/kg/day; p.o.) administration caused a significant increase in kidney weight to 129% while RST (10 mg/kg/day; p.o.) administration caused a non-significant increase in kidney weight to 125% when compared to cisplatin control group
Summary
Cisplatin (cis-diamminedichloroplatinum II) was accidentally discovered over four decades ago, and since it has widely been used for chemotherapy (Arany and Safirstein, 2003; Wang and Lippard, 2005). Two main factors generally limit cisplatin use and efficacy: acquired resistance to cisplatin and severe adverse effects in normal tissues; the latter being the major limiting factor (Wang and Lippard, 2005). These adverse include nephrotoxicity, ototoxicity, Cisplatin accumulates in proximal tubules where cisplatin concentration being about five times higher than the serum concentration leading to nephrotoxicity (Kodama et al, 2014). Cisplatininduced nephrotoxicity is considered an ideal model for studying the early pathophysiological features of acute nephrotoxicity (Safirstein et al, 1986; Ozkok and Edelstein, 2014)
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