Cisplatin and Hyponatremia

Abstract

Letters and Corrections1 May 1988Cisplatin and HyponatremiaXAVIER MARIETTE, M.D., BERNARD PAULE, M.D., PASCAL BENNET, M.D., DIDIER CLERC, M.D., MICHEL BISSON, M.D., PIERRE MASSIAS, M.D.XAVIER MARIETTE, M.D.Search for more papers by this author, BERNARD PAULE, M.D.Search for more papers by this author, PASCAL BENNET, M.D.Search for more papers by this author, DIDIER CLERC, M.D.Search for more papers by this author, MICHEL BISSON, M.D.Search for more papers by this author, PIERRE MASSIAS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-108-5-770_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Hutchinson and associates (1) reported renal salt wasting in 7 of 70 patients treated with cisplatin. These patients had severe persistent orthostatic hypotension requiring prolonged treatment with fludrocortisone and sodium chloride supplements. Six of these patients had hyponatremia (116 to 132 mmol/L). Plasma renin activity and aldosterone concentration were low. The stimulation of vasopressin activity by the resultant hypovolemia might account for the hyponatremia.Of 20 patients treated with cisplatin during the last 2 years for skeletal metastases, we observed six episodes of transient hyponatremia (less than 130 mmol/L) without symptomatic orthostatic hypotension in 3...