Abstract
The X-ray crystal structure of cis-[PtCl2(NH3){2-(2-hydroxyethyl)pyridine}] shows that it has similar structural features to the 2-picoline analogue, the anticancer drug AMD473 (ZD0473), but undergoes aquation much more rapidly. The diaqua adduct has unusually low pKa values which have been rationalised by molecular modelling. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)
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