Abstract

6-Aminomethylnicotinic acid ( 1a) and 2-aminomethylisonicotinic acid ( 1b) were each reacted with K 2PtCl 4 in aqueous 1 M HCl to give the corresponding N, N-chelated cis-dichloroplatinum(II) complexes 2. These were converted into amides 3 via their mixed anhydrides by treating them first with ethyl chloroformate and then with the respective 1° or 2° amine. The analogous 6-aminomethylnicotinic acid ester complexes 7 were obtained by reaction of the preformed ligands with K 2PtCl 4.

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