Abstract
Three undescribed cis-clerodane lactones, scapanialides A–C (1–3), and a new cis-clerodane furano-diterpenoid, scaparvin F (4), were isolated from the Chinese liverwort Scapania parva Steph. Scapanialide B (2) is the first cis-clerodane diterpenoid with a bicyclo[5.4.0]undecane skeleton from liverworts. Their structures including the absolute configurations were determined by extensive analysis of multidimensional NMR spectroscopy and TDDFT CD calculations, together with crystal X-ray diffraction measurements. The cytotoxicity of compounds 1–4 was preliminary tested against the Hela and MCF-7 cell lines.
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