Abstract
Cirsium setidens Nakai, a wild perennial herb, grows mainly in Kangwon province, Korea, and it has been reported to contain bioactive ingredients with various medicinal activities including treat edema, bleeding and hemoptysis. However, the potentiality of anti‐obesity effects of C. setidens Nakai has not been fully investigated. To characterize anti‐obesity effect of C. setidens Nakai extract (CNE) and to evaluate its potential as a functional food, we performed various obesity‐related in vitro experiments. In adipogenesis assay, CNE blocked the differentiation of 3T3‐L1 preadipocyte in a dose‐dependent manner. Exposure 200 μg/mL, CNE significantly reduced lipid accumulation (~40%). In addition, CNE suppressed the expression of lipogenic genes, while increasing the expression of lipolytic genes. The anti‐adipogenic and anti‐lipogenic effect of CNE seems to be mediated by the inhibition of PPARγ and C/EBPα, C/EBPβ, C/EBPδ expression. Moreover, CNE stimulated fatty acid oxidation in an AMPK‐dependent manner. These results showed anti‐obesity effects of CNE on adipogenesis and lipid metabolism in vitro and raised a possibility of developing the treatment of obesity as non‐toxic natural resources.
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