Abstract
BACKGROUND: To evaluate the Cirrus High-Definition Optical Coherence Tomography (OCT) features of the retina of rats. MATERIAL AND METHODS: Sixteen eyes of 16 adult BN rats were used. Histologic sections and OCT images of normal retinas and retinas with laser-induced choroidal neovascularization were studied. RESULTS: OCT showed a double-layered structure in the normal retina with a highly reflective layer located in the inner retina and a low reflective layer located in the outer retina. The retinal pigment epithelium (RPE) and choriocapillaris were imaged as a layer with the highest reflection. On the first day after photocoagulation, OCT image showed a disruption of the highly reflective layer corresponded to the RPE and choriocapillaris. Choroidal neovascularisation was seen as a highly reflective area located beneath the subretinal space. The retinal atrophy which appeared 4 weeks after photocoagulation was seen as a thinning reflection of the sensory retina. The retinal layer and thickness maps provided additional information that greatly complemented the OCT images. The histopathological appearance was well correlated with the OCT images. CONCLUSIONS: Cirrus OCT image combined with retinal layer and thickness maps will be a useful tool for the evaluation of animal studies of choroidal neovascularization and other retinal diseases.
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