CIRCULATORY EFFECTS OF A HOMOLOGOUS PLASMA-BLOOD EXCHANGE IN THE DOG.

Abstract

Abstract : The effect on plasma and red cell volume and protein concentration of exchanging homologous plasma for the dogs' own blood before a hemorrhage to 35 mm Hg mean arterial pressure was tested in morphine-pentobarbitalized dogs. The exchange was accomplished by bleeding the animals from an artery (44 cc/kg of blood) and at the same rate simultaneously infusing homologous plasma (44 cc/kg) through a vein. The measured cell and plasma volumes and protein concentration were in good agreement with the expected after the exchange. Therefore, homologous plasma successfully replaced the dogs' plasma removed during the exchange, and no reaction was seen attributable to the plasma infusion. When these animals were subjected to hemorrhage, the mean bleeding volume was 30% to reach a level of 35 mm Hg arterial pressure in contrast to 46% for dogs not receiving an exchange. Also 5.9 cc/kg of plasma and 0.46 gm/kg of protein has escaped from the circulation while previously there was mobilization of fluid and protein after a hemorrhage.