Circulatory effect of several cerebral circulatory drugs in man, with special reference to aminophylline, papaverine, cyclandelate, vincamine, prostaglandin E1 and isoxsuprine.

Abstract

Circulatory effects of several circulatory drugs, aminophylline, papaverine, cyclandelate, vincamine, prostaglandin E1 and isoxsuprine, on cerebral blood flow (blood flow in the internal carotid artery), brachial blood flow, heart rate and systolic blood pressure were investigated by means of the on-line Doppler ultrasonic technique in 33 apparently healthy males over 60 years of age, simultaneously and continuously in situ. (1) A biphasic cerebral blood flow response was induced by intravenous aminophylline, i.e., conspicuous and sustained decrease of blood flow from during to a short time after the administration, and conspicuous but transient increase of blood flow around 1 to 2 minutes after the administration. (2) A conspicuous but transient increase of cerebral blood flow was induced by intravenous papaverine. (3) A moderate or conspicuous and prolonged increase of cerebral blood flow was induced by intravenous cycladelate and vincamine. (4) Alteration of cerbral blood flow varied with intravenous prostaglandin E1 as follows. (i) No alteration of blood flow --4 subjects. (ii) Slight decrease or increase of blood flow--2 subjects each. (5) No alteration or slight increase of cerebral blood flow was induced by intramuscular isoxsuprine. (6) The findings coincide well with those obtained previously.