Abstract
The circulatory and pulmonary airway resistance responses to intravenous administration of 3 different ratios (10 : 1, 1 : 1, 1 : 5) of PGE 2-PGF 2α were studied in anesthetized dogs. It was found that these mixtures of PGE 2-PGF 2α cause a dose-related decrease in systemic arterial pressure and a dose-related increase in pulmonary arterial pressure and airway pressure. It was concluded that there is evidence of marked differences in tissue specificity even when these different prostaglandins were given simultaneously, indicating that a preferential synthesis of PGE 2 or PGF 2α is not essential for the pathogenesis of clinical disorders with inflammatory reactions and bronchospasm, respectively.
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